Thirty-eight of 39 (97%) meningiomas with MIB-1 labeling index greater than 5.0 exhibited mitotic indices of more than 1. Necrosis, prominent nucleoli, loss of Results: Of the 40 meningiomas studied 21 were benign, 16 atypical and 3 anaplastic. Atypical tumors had a higher MIB-1 LI than benign tumors, with diagnostic Mar 11, 2002 The objective of this study was to formulate diagnostic criteria for atypical meningioma. METHODS. Eighty‐three patients with meningiomas who Prayson, (1999) Histopathologic Features and MIB-1 Labeling Indices in Recurrent and Nonrecurrent Meningiomas. Archives of Pathology & Laboratory Medicine: Malignant meningiomas were characterized by brain invasion or metastasis. The MIB-1 Us (% positive tumor cell nuclei) were compared between the three groups
Results: Of the 40 meningiomas studied 21 were benign, 16 atypical and 3 anaplastic. Atypical tumors had a higher MIB-1 LI than benign tumors, with diagnostic
In subsequently analyzed materials from 94 skull base and 116 non-skull base symptomatic meningiomas, the mean MIB-1 index for skull base tumors was markedly low (2.09%), compared with that for non-skull base tumors (2.74%; p = 0.013). Skull base IDMs tend not to grow, which is different from non-skull base tumors. The mean ± SD MIB index was 2.23±2.31 in grade I meningiomas, and those of grade II and grade III meningiomas were 6.53±5.31 and 11.1±7.8, respectively. There was a correlation between the values of MIB-1 LI and the histological grades. Meningiomas have also a wide range of histopathological appearances. Malignant meningiomas were characterized by brain invasion or metastasis. The MIB-1 Us (% positive tumor cell nuclei) were compared between the three groups (Kruskal-Wallis test, Wilcoxon two-sample test). Of the benign meningiomas ( n = 37; mean age, 54 years), 41% had one of the six histological features, The mitotic index, measured by pHH3 immunohistochemistry, is a predictor of recurrence in meningioma independent of grade and MIB-1 index. Moreover, our data shows that within the WHO grade I and II meningiomas more aggressive tumors are nested.
MIB1 staining index and scoring of histologic features in meningioma. Indicators for the prediction of biologic potential and postoperative management. Ohta M(1), Iwaki T, Kitamoto T, Takeshita I, Tateishi J, Fukui M. Author information: (1)Department of Neurosurgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
The MIB-1 index can differentiate tumors with a high risk of recurrence, which could be beneficial for planning tailored optimal follow-up strategies. The results of this study appear to provide a significant backing for the recent shift in meningioma surgery from attempting aggressive resection to valuing the quality of the patient's life.
and Ki-67 proliferation index in meningiomas. Akyildiz EU1, Oz Key words: meningioma, MIB-1, proliferative potential, recurrence, invasion. Meningiomas are
The proliferative marker, MIB-1 labeling index, is a useful method for this purpose. However, several reports state that the MIB-1 labeling index is not an appropriate method with which to evaluate the malignant potential and recurrence rate of RIMs [12, 18]. All of the lesions in our RIM case had high MIB-1 labeling indices, and the tumor The aim of this study was to assess the prognostic value of the Ki-67/MIB-1 labeling index (LI) in human meningiomas by a search in the literature. In PubMed/Medline databases, 53 articles were found, and they all showed positive correlations between Ki-67/MIB-1 LI and histological malignancy grade. The proliferation index Ki67 (Ki67 index), assessed as the percentage of MIB-1 positive cells in the area of greatest proliferation, is the most frequently used proliferation index for meningiomas.
Meningiomas are generally negative for GFAP. . MIB-1 labeling index correlates with grade and recurrence rate with an index greater than 4% associated with
The MIB-1 index can differentiate tumors with a high risk of recurrence, which could be beneficial for planning tailored optimal follow-up strategies. The results of this study appear to provide a significant backing for the recent shift in meningioma surgery from attempting aggressive resection to valuing the quality of the patient's life. The Simpson grade of meningioma resection was described in 1957 and correlated the degree of surgical resection completeness with symptomatic recurrence 1. Although the type of resection still plays a part in the likelihood of symptomatic recurrence, other factors (such as the MIB-1 index) are also important, particularly in grades I - III 2 . The MIB-1 labeling index (LI) for the entire group studied ranged from 0.4 to 33.5 (mean LI, 8.4). Fifty-two tumors with an LI of < 10 did not recur within 10 years. Of the 31 tumors with an LI > or = 10, 97% recurred (71% within 5 years). CONCLUSIONS: Histopathology and MIB-1 LI were able to predict clinical outcomes of patients with meningioma. This work investigates the MIB-1 staining index (SI) of meningiomas in the pediatric age group, a cohort not previously studied. Because meningiomas are less common in this age group, the number of cases is small and this unfortunately limits the extent to which the authors can draw general conclusions. Predicting tumor behavior in meningiomas based on histology alone has been problematic. This study retrospectively compares histology and MIB-1 (cell proliferation marker) labeling indices (LI) in benign, aggressive, and malignant meningiomas. Although they were assigned high MIB-1 values by the HL method, these meningiomas did not recur, and therefore obscured the prognostic importance of the MIB-1 value with the HL method. Focal accumulation of MIB-1-positive cells in meningiomas is not likely to correlate with their biologic aggressiveness.
May 10, 2018 determining the grade and cellular proliferation of meningiomas. MIB-1 labeling index in human meningiomas: a literature study. Pathol Res Jan 29, 2018 In the present study, 246 cases of meningioma were reclassified and MIB-1 labelling index predicted recurrence of meningiomas: a proposal Meningiomas are generally negative for GFAP. . MIB-1 labeling index correlates with grade and recurrence rate with an index greater than 4% associated with